Level of maternal respiratory syncytial virus (RSV) F antibodies in hospitalized children and correlates of protection
نویسندگان
چکیده
BackgroundRespiratory syncytial virus (RSV) is a major cause of lower respiratory infection among children and no vaccine available. The stabilized form the fusion (F) protein – pre-F leading candidate to target different populations, including pregnant women. This study aimed determine magnitude nature RSV-directed maternal antibodies (matAbs) in hospitalized with RSV infection.MethodsSixty-five paired blood samples were collected from RSV-infected aged <6 months their corresponding mothers. All pairs screened for levels post-F using ELISA. neutralizing (NAbs) both groups measured vitro against mKate RSV-A2 H28 cells.ResultsIt was found that 14% matAbs (log2 12.8) present infants at hospitalization, an average log2 EP titer 10.2 directed F-protein conformations. Additionally, 61.4% NAbs EC50 = 9.4) detected 8.7), which mostly exclusive (81%). Pre-F showed positive correlation titers negative correlations age bronchiolitis score.ConclusionsThe maintenance activity relative greater than antibody binding based on ELISA, suggesting higher-potency may have longer half-life weakly antibodies.
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ژورنال
عنوان ژورنال: International Journal of Infectious Diseases
سال: 2021
ISSN: ['1878-3511', '1201-9712']
DOI: https://doi.org/10.1016/j.ijid.2021.06.015